Lucille Bliss

Lucille Bliss (March 31, 1916 – November 8, 2012) was an American actress, known in the Bay Area and in Hollywood as the "Girl With a Thousand Voices". Bliss lent her voice to numerous television characters, including the title character of the very first made-for-television cartoon, Crusader Rabbit, Smurfette on the popular 1980s cartoon The Smurfs, and Ms. Bitters on the Nickelodeon animated series Invader Zim. In addition to her television roles, she was known for her work as a voice actress in feature films.

[biography (excerpted) from Wikipedia]